BACKGROUND In a recent trial, targeted mild hypothermia in brain dead organ donors significantly reduced the incidence of delayed graft function (DGF) after kidney transplantation. This trial was stopped early for efficacy. Here, we report long-term graft survival for all organs along with donor critical care endpoints. METHODS We assessed graft survival through one year of all solid organ transplanted
from 370 donors who had been randomly assigned to hypothermia (34-35degreeC) or normothermia (36.5-37.5degreeC) prior to donation. Additionally, changes in standardized critical care endpoints were compared between donors in each group. RESULTS Mild hypothermia was associated with a nonsignificant improvement in one-year kidney transplant survival (95% vs. 92%, hazards ratio [HR] 0.61 [0.31-1.20], p=0.15). Mild hypothermia was associated with higher one-year graft survival in the subgroup of standard criteria donors (97% vs. 93%, HR 0.39 [0.15 -1.00], p=0.05). There were no significant differences in graft survival of extra-renal organs. There were no differences in critical care endpoints between groups. CONCLUSIONS Mild hypothermia in the donor safely reduced the rate of DGF in kidney transplant recipients without adversely affecting donor physiology or extra-renal graft survival. Kidneys from standard criteria donors who received targeted mild hypothermia had improved one-year graft survival.
Dr Liset Pengel, Centre for Evidence in Transplantation, Nuffield Department of Surgical Sciences University of Oxford
This article reports a post-hoc analysis of recipients receiving organs from brain dead donors who had undergone either mild hypothermia (34-35°C) or normothermia (36.5-37.5°C). The primary analysis was previously published and the intervention was considered potentially practice changing (https://www.transplantlibrary.com/article/26222557). Targeted temperatures were achieved by using external cooling devices. Follow-up data of 565 kidney, 262 liver, 94 heart, 99 lung and 25 pancreas transplants were obtained from national registries. There were no statistically significant difference in the adjusted and unadjusted 1-year kidney graft survival rates, however a subgroup analysis by donor type showed that the graft survival rate was significantly higher
in standard criteria donors undergoing hypothermia, also when adjusted for cold ischemia time. The 1-year adjusted and unadjusted graft survival rates for liver, heart, lung and pancreas transplants showed no statistically significant differences between the groups.