ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation

J Heart Lung Transplant. 2020 Apr;39(4):331-341 doi: 10.1016/j.healun.2020.01.1345.
Abstract

The number of potential pediatric heart transplant recipients continues to exceed the number of donors, and consequently the waitlist mortality remains significant. Despite this, around 40% of all donated organs are not used and are discarded. This document (62 authors from 53 institutions in 17 countries) evaluates factors responsible for discarding donor hearts and makes recommendations regarding donor heart acceptance. The aim of this statement is to ensure that no usable donor heart is discarded, waitlist mortality is reduced, and post-transplant survival is not adversely impacted.

Metadata
Organisation: Kirk, Richard. Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Children's Medical Center, Dallas, Texas. Electronic address: richard@crkirk.com. Dipchand, Anne I. Labatt Family Heart Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. Davies, Ryan R. Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Children's Medical Center, Dallas, Texas. Miera, Oliver. Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany. Chapman, Gretchen. Carnegie Mellon University, Pittsburgh, Pennsylvania. Conway, Jennifer. Department of Pediatrics, Division of Pediatric Cardiology, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada. Denfield, Susan. Texas Children's Hospital, Baylor College of Medicine, Houston, Texas. Gossett, Jeffrey G. University of California Benioff Children's Hospitals, San Francisco, California. Johnson, Jonathan. Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota. McCulloch, Michael. University of Virginia Children's Hospital, Charlottesville, Virginia. Schweiger, Martin. Division of Pediatric Cardiology, Pediatric Heart Center, University Children's Hospital Zurich, Zurich, Switzerland. Zimpfer, Daniel. Department of Cardiac Surgery, Vienna and Pediatric Heart Center Vienna, Vienna, Austria. Ablonczy, Laszlo. Pediatric Cardiac Center, Hungarian Institute of Cardiology, Budapest, Hungary. Adachi, Iki. Texas Children's Hospital, Baylor College of Medicine, Houston, Texas. Albert, Dimpna. King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. Alexander, Peta. Department of Cardiology, Boston Children's Hospital Department of Pediatrics, Harvard Medical School, Boston, Massachusetts. Amdani, Shahnawaz. Cleveland Clinic Children's Hospital, Cleveland, Ohio. Amodeo, Antonio. Bambino Gesu Hospital, Rome, Italy. Azeka, Estela. Heart Institute (InCor) University of Sao Paulo, Sao Paulo, Brazil. Ballweg, Jean. Department of Pediatrics, Division of Pediatric Cardiology, Children's Hospital and Medical Center University of Nebraska Medical Center, Omaha, Nebraska. Beasley, Gary. Le Bonheur Children's Hospital, Memphis, Tennessee. Bohmer, Jens. Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden. Butler, Alison. Carnegie Mellon University, Pittsburgh, Pennsylvania. Camino, Manuela. Madrid Hospital Gregorio Maranon, Madrid, Spain. Castro, Javier. Fundacion Cardiovascular de Colombia, Santander, Bucaramanga City, Colombia. Chen, Sharon. Stanford University, Palo Alto, California. Chrisant, Maryanne. Heart Institute, Joe Dimaggio Children's Hospital, Hollywood, Florida. Christen, Urs. Oslo University Hospital Rikshospitalet, Oslo, Norway. Danziger-Isakov, Lara. Pediatric Infectious Diseases, Cincinnati Children's Hospital Medical Center & University of Cincinnati, Cincinnati, Ohio. Das, Bibhuti. Heart Institute, Joe Dimaggio Children's Hospital, Hollywood, Florida. Everitt, Melanie. Children's Hospital Colorado, Denver, Colorado. Feingold, Brian. Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Fenton, Matthew. Great Ormond Street Hospital for Children Foundation Trust, London, United Kingdom. Garcia-Guereta, Luis. Hospital Universitario La Paz, Madrid, Spain. Godown, Justin. Vanderbilt University Medical Center, Nashville, Tennessee. Gupta, Dipankar. Congenital Heart Center, University of Florida, Gainesville, Florida. Irving, Claire. Children's Hospital Westmead, Sydney, New South Wales, Australia. Joong, Anna. Ann and Robert H. Lurie Children's Hospital, Chicago, Illinois. Kemna, Mariska. Seattle Children's Hospital, Seattle, Washington. Khulbey, Sanjeev Kumar. Apollo Hospital, Hyderabad, India. Kindel, Steven. Children's Hospital of Wisconsin, Milwaukee, Wisconsin. Knecht, Kenneth. Arkansas Children's Hospital, Little Rock, Arkansas. Lal, Ashwin K. University of Utah, Salt Lake City, Utah. Lin, Kimberly. The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Lord, Karen. New England Organ Bank, Boston, Massachusetts. Moller, Thomas. Oslo University Hospital Rikshospitalet, Oslo, Norway. Nandi, Deipanjan. Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio. Niesse, Oliver. Division of Pediatric Cardiology, Pediatric Heart Center, University Children's Hospital Zurich, Zurich, Switzerland. Peng, David M. University of Michigan, Ann Arbor, Michigan. Perez-Blanco, Alicia. Spanish National Transplant Organization, Madrid, Spain. Punnoose, Ann. Children's Hospital of Wisconsin, Milwaukee, Wisconsin. Reinhardt, Zdenka. Freeman Hospital, Newcastle upon Tyne, United Kingdom. Rosenthal, David. Stanford University, Palo Alto, California. Scales, Angie. Pediatric and Neonatal Donation and Transplantation, Organ Donation and Transplantation, NHS Blood and Transplant, London, United Kingdom. Scheel, Janet. Washington University School of Medicine, St. Louis, Missouri. Shih, Renata. Congenital Heart Center, University of Florida, Gainesville, Florida. Smith, Jonathan. Freeman Hospital, Newcastle upon Tyne, United Kingdom. Smits, Jacqueline. Eurotransplant International Foundation, Leiden, Netherlands. Thul, Josef. Children's Heart Center, University of Giessen, Giessen, Germany. Weintraub, Robert. Royal Children's Hospital, Melbourne, Victoria, Australia. Zangwill, Steve. Phoenix Children's Hospital, Phoenix, Arizona. Zuckerman, Warren A. Columbia University Medical Center, Morgan Stanley Children's Hospital of New York, New York, New York.
Funding: No funding was received for this study
Publication type: Guideline
Organ: Heart
Language: English
MeSH terms: Child; Consensus; Donor Selection; Graft Survival; Heart Transplantation; Humans; Risk Assessment; Tissue Donors; Tissue and Organ Procurement; Waiting Lists