Effectiveness of a health communication intervention on health literacy in the first year following kidney transplantation - A randomized controlled study

Patient Educ Couns. 2024 Jun;123:108207 doi: 10.1016/j.pec.2024.108207.

This study aimed to evaluate the effect of a new health communication intervention focusing on knowledge management skills on health literacy and medication adherence during the first year following kidney transplantation.


We randomized 195 patients during 2020-2021, to either intervention- or control group. Questionnaires were completed at baseline and at 12 months post-transplantation with a 12-month response rate of 84%. Health literacy was measured by the multidimensional Health Literacy Questionnaire (HLQ) instrument. Medication adherence was measured by the self-reported questionnaire (BAASIS©).


Results showed that the intervention group had a significant increase in 2 HLQ domains compared to the control group capturing the "ability to appraise health information" Domain 5, (p-value = 0.002) and the "ability to navigate the healthcare system" Domain 7, (p-value <0.04). The effect sizes of SRM were 0.49 (Domain 5) and 0.33 (Domain 7). Medication adherence was comparable in the groups at any measure points.


This study contributes to important knowledge about how a health communication intervention focusing on knowledge translation using motivational interviewing techniques positively strengthens health literacy in kidney transplant recipients.


Current patient education practice may benefit from focusing on knowledge translation in combination with motivational interview technique.

Methodological quality
Jadad score 2
Allocation concealment YES
Funding: Non-industry funding
Publication type: Randomized Controlled Trial, Randomised Controlled Trial
Trial registration: ClinicalTrials.gov - NCT04296955
Organ: Kidney
Language: English
Author email: tvidnes@ous-hf.no
MeSH terms: Humans; Health Communication; Kidney Transplantation; Health Literacy; Research Design; Surveys and Questionnaires; Medication Adherence