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  • Mozes MF
  • Finch WT
  • Reckard CR
  • et al,
Transplant Proc. 1985;17(1 II):1474-1477.
  • Halloran P
  • Aprile M
  • Robinette M
  • et al,
Transplant Proc. 1985;17(1 II):1471-1473.
  • Toledo-Pereyra LH
Bol Asoc Med P R. 1983 Aug;75(8):347-50.
  • Light JA
  • Metz S
  • Oddenino K
  • Simonis T
  • Strong DM
  • et al.
Transplant Proc. 1982 Jun;14(2):296-301.

Haploidentical, MLC responsive recipients were randomized to receive either fresh (less than 48 hours old) or stored donor specific transfusions (DST). In the stored DST group, one donor unit obtained with CPD-Adenine anticoagulant was split into three aliquots and administered as packed cells after 1, 3, and 5 weeks of storage. While 3/6 fresh DST recipients became sensitized to their donors, 0/12 receiving stored DSTs developed positive donor crossmatches. Eleven patients (three fresh, eight stored) have been transplanted and have had similar posttransplant courses. None of the stored DST recipients has rejected his transplant. Four recipients of stored DSTs are awaiting transplantation. Leukocyte enumeration and FACS analysis of aliquots of stored blood shown that cells bearing HLA-ABC antigens disappear with time while B cells and monocytes persist. Taken in concert, the observations suggest that favorable recipient conditioning for transplantation can take place without sensitization to HLA antigens by simply storing the blood prior to transfusion.

  • Cho SI
  • Bradley JW
  • Garovoy MR
  • Nabseth DC
Am J Surg. 1981 Apr;141(4):441-5 doi: 10.1016/0002-9610(81)90137-9.

A controlled prospective study was conducted to compare the results of kidney preservation and transplantation in regard to the type of perfusate used for perfusion preservation. Cryoprecipitated plasma, plasma protein fraction and serum albumin solution were used as perfusate. Between February 1979 and July 1980, 176 kidneys were preserved by one of these perfusates and transplanted. There was no statistically significant difference in the donor and recipient status, perfusion characteristics or graft and patient survival among the three groups. Synthetic perfusates are an acceptable alternative to cryoprecipitated plasma for perfusion preservation of cadaver kidneys.

  • Marshall VC
  • Toledo-Pereyra LH
J Surg Res. 1980 Jun;28(6):563-70 doi: 10.1016/0022-4804(80)90049-9.
  • Beck TA
Transplant Proc. 1979 Mar;11(1):459-64.
  • Chatterjee SN
  • Terasaki PI
  • Fine S
  • Schulman B
  • Smith R
  • et al.
Surg Gynecol Obstet. 1977 Nov;145(5):729-32.

Fifty cadaveric kidney donors were randomly allocated to two groups. Group 1 received 5 grams of intravenously administered methylprednisolone two to four hours prior to organ harvesting after the pronouncement of brain death. Group 2, which served as the control group, received no pretreatment. Of 100 kidneys harvested, 16 were discarded for various reasons, and 84 were transplanted and were available for evaluation, 40 from the pretreatment group and 44 from the control group. The transplant centers using these kidneys were unaware of the status of the kidney they received, that is, whether it was from a pretreated or a control group. The two groups of kidneys, pretreated and control, did not differ according to the length of warm or cold ischemia time or presence of preformed cytotoxic antibodies. The difference in graft failure between the two groups at three months was insignificant, even when the two groups were compared according to the method of preservation used.

  • Marshall VC
  • Ross H
  • Scott DF
  • McInnes S
  • Thomson N
  • et al.
Med J Aust. 1977 Sep 10;2(11):353-6.

Preservation of cadaveric renal allografts by ice storage and by machine perfusion after a preliminary flush with a hypertonic citrate solution has been compared in a prospective clinical trial between matched pairs of kidneys from the same cadaver donor. Over a two-year period, ice storage after flushing with the new solution gave results comparable with machine perfusion. Times of warm ischaemia and total times of storage were similar in ice-stored and machine-perfused kidneys and averaged about 16 hours. In each group of recipients, more than half of the kidneys had good early function and one-year survival times were also similar.